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Hormone Imbalance

Conditions that can develop from hormonal imbalance, and will respond favourably to Naturone Progesterone Therapy


1. Side effects of natural progesterone

There are none.

2.What is progesterone?

PROGESTERONE is a hormone that has been around for about 500 million years. That makes it the oldest hormone.

Progesterone is essential to all vertebrates including reptiles, fish, birds and mammals (including humans) and plays an important role in both sexes including stabilising blood sugar, building bones, and developing intelligence and brain activity. It is also involved in the reproduction of mammals as it is from this hormone that oestrogen and testosterone are converted as well as many others.

Here are the essentials...

Progesterone is made in our body from cholesterol. This is broken down into pregnenolone and then into progesterone. Your body then makes the other hormones that it needs from the progesterone.

This is a vital point to understand... progesterone is the essential raw material from which your body makes the other hormones. It is this simple fact that helps anyone appreciate just how wide ranging the effects of a defficiency can be.

Itís value lies in is itís ability to keep your homones in balance, and in this way alleviate all disease caused by out of balance hormones.

It is in reproduction that women need more PROGESTERONE than men to supply enough to the growing foetus. Men still need progesterone however to keep their hormones in balance as well as many other functions.

3.Why do we need to supplement our progesterone?

In an unstressful and unpolluted world there would be no need to supplement progesterone.

Stress depletes our progesterone and todayís lifestyle is extremely stressful, thus depleting our reserves. To add to that fact is the pollution of the whole planet bu many different man made chemicals that disrupt our hormones by supplying us with too much oestrogen. Progesterone is the only way to counteract that effect.

As an example: Progesterone is needed in hormone replacement therapy for menopausal women for many reasons, but one of its most important roles is to balance or oppose the effects of oestrogen. Unopposed oestrogen creates a strong risk for breast cancer and reproductive cancers.

Oestrogen levels drop only 40-60% at menopause, which is just enough to stop the menstrual cycle. But progesterone levels may drop to near zero in some women. Because progesterone is the precursor to so many other steroid hormones, its use can greatly enhance overall hormone balance after menopause. Progesterone also stimulates bone-building and thus helps protect against osteoporosis.

4. Why not just use the progestin Provera as prescribed by some doctors?

Progesterone is preferable to the synthetic progestins such as Provera, because it is natural to the body and has no undesirable side effects when used as directed.

If you have any doubts about how different progesterone is from the progestins, remember that the placenta produces 300-400 mg of progesterone daily during the last few months of pregnancy, so we know that such levels are safe for the developing baby. But progestins, even at fractions of this dose, can cause birth defects. The progestins also cause many other side effects, including partial loss of vision, breast cancer in test dogs, an increased risk of strokes, fluid retention, migraine headaches, asthma, cardiac irregularities and depression. (Link to Medical papers)

5. What is estrogen dominance?

A: Dr. Lee (link to Reading List) has coined the term "oestrogen dominance," to describe what happens when the normal ratio or balance of oestrogen to progesterone is changed by excess oestrogen or inadequate progesterone. Oestrogen is a potent and potentially dangerous hormone when not balanced by adequate progesterone.

Both women who have suffered from PMS and those who have suffered from menopausal symptoms, will recognize the hallmark symptoms of oestrogen dominance: weight gain, bloating, mood swings, irritability, tender breasts, headaches, fatigue, depression, hypo-glycemia, uterine fibroids, endometriosis, and fibrocystic breasts. Oestrogen dominance is known to cause and/or contribute to cancer of the breast, ovary, endometrium (uterus), and prostate.

6.Does a pre-menopausal woman need progesterone cream?

In the ten to fifteen years before menopause, many women regularly have anovulatory cycles in which they make enough oestrogen to create menstruation, but they don't make any progesterone, thus setting the stage for oestrogen dominance. Using progesterone cream can help prevent the symptoms of PMS.

We now know that PMS can occur despite normal progesterone levels when stress is present. Stress increases cortisol production; cortisol blockades (or competes for) progesterone receptors. Additional progesterone is required to overcome this blockade, and stress management is important.

7. What is progesterone made from?

The progesterone comes from plant fats and oils, usually a substance called diosgenin which is extracted from a very specific type of wild yam that grows in Mexico, or from soybeans. In the laboratory diosgenin is chemically synthesized into real human progesterone. The other human steroid hormones, including estrogen, testosterone, progesterone and the cortisones are also nearly always synthesized from diosgenin. By real human progesterone we mean the bio-identical hormone that is found in the human body.

Some companies are trying to sell diosgenin, which they label "wild yam extract" as a medicine or supplement, claiming that the body will then convert it into hormones as needed. While we know this can be done in the laboratory, there is no evidence that this conversion takes place in the human body.

8. Is progesterone cream safe?

During the third trimester of pregnancy, the placenta produces about 300 mg of progesterone daily, so we know that a one-time overdose of the cream is virtually impossible. If you used a whole jar at once it might make you sleepy. However, Dr. Lee recommends that women avoid using higher than the recommended dosage to avoid hormone imbalances.

9. Wouldn't it be easier to just take a progesterone pill?

Dr. Lee recommends the trans-dermal cream rather than oral progesterone, because some 80% to 90% of the oral dose is lost through the liver. Thus, at least 200 to 400 mg daily is needed orally to achieve a physiologic dose of 15 to 24 mg daily. Such high doses create undesirable metabolites and unnecessarily overload the liver.

For a detailed explanation of women's hormone balance issues, a hormone balance program, as well as detailed descriptions of how to use natural progesterone, the following books by John R. Lee, M.D. are recommended:
  • What Your Doctor May Not Tell You About Menopause: The Breakthrough Book on Natural Progesterone, (Warner Books, 1996)
  • What Your Doctor May Not Tell You About Pre menopause: Balance Your Hormones and Life from Thirty to Fifty (Warner Books, 1999)


Naturone is made to the highest standards using the purest products using grapefruit extract as a preservative. It is natural to our bodies and has no animal derivatives, nor is it tested on animals. It can therefore be used by all, irrespective of dietary, environmental or religious concerns. It has a pH of 5.5 which is in balance with that of the skin.

Each jar contains 2000mg of natural progesterone making it extremely cost effective.

It is exported worldwide.




  1. Side effects of natural progesterone
  2. What is progesterone?
  3. Why do we need to supplement our progesterone?
  4. Why not just use the progestin Provera as prescribed by some doctors?
  5. What is estrogen dominance?
  6. Does a pre-menopausal woman need progesterone cream?
  7. What is progesterone made from?
  8. Is progesterone cream safe?
  9. Wouldn't it be easier to just take a progesterone pill?
  10. Why NATURONE?

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